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Pinakauna so haring Sargon l, Hammurabi, at Nebuchadnezzar ang mga natatanging mga pinuno sa mesopotamia. Hindi po imperyo ang mesopotamia, Ito po ay isang pook.
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Akkad-Sargon I at Naram Sin
Assyrian-Tiglath Pileser at ashurbanipal
Chaldean-Nabopalassar at nebuchadnezzar
persian-Cyrus the great at Darius the great 

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