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It actually depends on what the drugs contain. If you mean the drugs they sell in drugstores for medication, then they heal your system or strengthen the immune systems of your body. They also sometimes relieve pain. If you are talking about the illegal drugs, then these are the ones that provide hallucinations, addictions and brain damage. These also may possibly take over the internal and external features of the body, making it more unhealthy.
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The overdosage of drugs, no matter what kind, medical or illegal, has negative effects. There is a "High" feeling. Overdosage can cause death