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The other parts will be affected and the organism might be sick or the system will lead to failure or in worse cases death.
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If parts of the heart were injured or diseases, it will make the organ system, which is circulatory system, to work improperly, circulatory system's work into our body is to deliver blood to the tissues, but we are just referring to heart here, so the blood may improperly travel trough the heart, or the heart may have difficulty in receiving blood, making the organism to be sick, or death. 
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