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The nucleotides differ from each other because of their pentose sugar and of their nitrogenous bases like:

                                   DNA                                       RNA

pentose sugar             ribose                                  deoxyribose
nitrogenous bases      A-T-G-C                                   A-U-G-C

DNA                       RNA
A- adenine              same
T- thymine              U- uracil
G- guanine              same
C- cytosine              same